![]() Resting platelets maintain active calcium efflux via a cyclic AMP-activated calcium pump. Endothelial-ADPase degrades the platelet activator ADP. The intact endothelial lining inhibits platelet activation by producing nitric oxide, endothelial- ADPase, and PGI 2 (prostacyclin). From left to right: human erythrocyte, activated platelet, leukocyte. Scanning electron micrograph of blood cells. ![]() More accurate biophysical models of the platelet surface morphology, which model its shape from first principles, make it possible to obtain a more realistic platelet geometry in a calm and activated state. This approximation is often used to model the hydrodynamic and optical properties of a platelet population, as well as to restore the geometric parameters of individual measured platelets by flow cytometry. In a first approximation, the platelet shape can be considered similar to oblate spheroids, with a semiaxis ratio of 2 to 8. Activated platelets have cell membrane projections covering their surface. This dense tubular system is connected to the surface platelet membrane to aid thromboxane A2 release.Ĭirculating inactivated platelets are biconvex discoid (lens-shaped) structures, : 117–18 2–3 µm in greatest diameter.
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